Moonlighting cell surface GAPDH recruits Apo Transferrin to effect iron egress from 1 mammalian cells
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چکیده
Moonlighting cell surface GAPDH recruits Apo Transferrin to effect iron egress from 1 mammalian cells 2 Navdeep Sheokand, Himanshu Malhotra, Santosh Kumar , Vikas Ajit Tillu, Anoop Singh 3 Chauhan, Chaaya Iyengar Raje and Manoj Raje∗ 4 Institute of Microbial Technology, CSIR, Sector 39A, Chandigarh, INDIA-160036. 5 2 National Institute of Pharmaceutical Education & Research, Phase X, Sector 67, SAS Nagar, 6 Punjab, INDIA-160062. 7 ∗ Correspondence: [email protected] 8 Phone: +91-172-6665198 9 Fax : +91-172-2690632 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 © 2014. Published by The Company of Biologists Ltd.
منابع مشابه
Apo Transferrin to effect iron egress from 1 mammalian cells
Moonlighting cell surface GAPDH recruits Apo Transferrin to effect iron egress from 1 mammalian cells 2 Navdeep Sheokand, Himanshu Malhotra, Santosh Kumar , Vikas Ajit Tillu, Anoop Singh 3 Chauhan, Chaaya Iyengar Raje and Manoj Raje∗ 4 Institute of Microbial Technology, CSIR, Sector 39A, Chandigarh, INDIA-160036. 5 2 National Institute of Pharmaceutical Education & Research, Phase X, Sector 67,...
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Iron (Fe(2+), Fe(3+)) homeostasis is a tightly regulated process, involving precise control of iron influx and egress from cells. Although the mechanisms of its import into cells by iron carrier molecules are well characterized, iron export remains poorly understood. The current paradigm envisages unique functions associated with specialized macromolecules for its cellular import (transferrin r...
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The reticuloendothelial system plays a major role in iron metabolism. Despite this, the manner in which macrophages handle iron remains poorly understood. Mammalian cells utilize transferrin-dependent mechanisms to acquire iron via transferrin receptors 1 and 2 (TfR1 and TfR2) by receptor-mediated endocytosis. Here, we show for the first time that the glycolytic enzyme glyceraldehyde-3-phosphat...
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Indium is a heavy metal belonging to group IIIa. It is believed that indium may interfere with iron metabolism from the sites of absorption, transportation, utilization and storage in the cells. The present investigation was established to study and compare the binding of iron and indium to human apo-transferrin (apo-tf). Pure human apo-tf was used and the binding activity of iron and indium, a...
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Indium is a heavy metal belonging to group IIIa. It is used as a radioimaging and chemotherapeutic agent in diagnosis and also in the treatment of cancers. It is believed that indium may interfere with iron metabolism and reduce cell growth in cancer tissue. The present report was established to study the binding of iron and indium to apo-transferrin (apo-tf) and to identify amino acids involv...
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